Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

Syamal Kumar Datta*, Chandra Mohan, Ami Desai-Mehta

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations


A major step towards understanding the basic mechanism of systemic lupus erythematosus (SLE), the prototypic autoimmune disease that develops spontaneously, has been the identification of nucleosomes as a primary immunogen in this disease. The production of pathogenic autoantibodies in SLE results from an MHC clas-II-restricted, cognate interaction between select populations of T helper cells and B cells that are specific for nucleosomal components. These observations pave the way for specific immunotherapy that blocks this pathogenic T and B cell interaction.

Original languageEnglish (US)
Pages (from-to)132-147
Number of pages16
JournalImmunologic Research
Issue number2
Publication statusPublished - Jun 1 1995



  • Anti-DNA autoantibodies
  • Autoimmune T cell receptors
  • CD40
  • CD40-ligand
  • Immunotherapy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology

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