Mechanisms of tubulointerstitial fibrosis

Michael Zeisberg*, Eric G. Neilson

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

573 Scopus citations

Abstract

The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis. Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades, effective human treatment to directly halt or even reverse fibrosis remains elusive. Here, we examine key features mediating the molecular and cellular basis of tubulointerstitial fibrosis and highlight new insights that may lead to novel therapies. How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding.

Original languageEnglish (US)
Pages (from-to)1819-1834
Number of pages16
JournalJournal of the American Society of Nephrology
Volume21
Issue number11
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Nephrology

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