Mechanisms of type-I interferon signal transduction

Shahab Uddin*, Leonidas C. Platanias

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Interferons regulate a number of biological functions including control of cell proliferation, generation of antiviral activities and immumodulation in human cells. Studies by several investigators have identified a number of cellular signaling cascades that are activated during engagement of interferon receptors. The activation of multiple signaling cascades by the interferon receptors appears to be critical for the generation of interferon-mediated biological functions and immune surveillance. The present review summarizes the existing knowledge on the multiple signaling cascades activated by Type I interferons. Recent developments in this research area are emphasized and the implications of these new discoveries on our understanding of interferon actions are discussed.

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalJournal of Biochemistry and Molecular Biology
Issue number6
StatePublished - Nov 30 2004


  • IRS/PI3′ kinase pathway
  • Interferons
  • Jak/Stat pathway
  • Signal transduction

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry


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