@article{2292907fff2a4d33a8ccaf139b0e3f84,
title = "Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar",
abstract = "Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macrovascular and microvascular diseases associated with old age. The role of cellular senescence in development of vascular aging phenotypes is highlighted, and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. The evidence supporting a role for interorgan communication and circulating progeronic and antigeronic factors in vascular aging is discussed.",
keywords = "atherosclerosis, endothelial dysfunction, geroscience, microcirculation, senescence",
author = "Zoltan Ungvari and Stefano Tarantini and Farzaneh Sorond and Bela Merkely and Anna Csiszar",
note = "Funding Information: This work was supported by grants from the American Heart Association (Dr. Tarantini), the Oklahoma Center for the Advancement of Science and Technology (to Dr. Csiszar and Dr. Ungvari), the Presbyterian Health Foundation (to Dr. Unvari and Dr. Csiszar), the National Institute on Aging–supported Geroscience Training Program in Oklahoma (T32AG052363), and the Cellular and Molecular GeroScience CoBRE (1P20GM125528). The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Funding Information: This work was supported by grants from the American Heart Association (Dr. Tarantini), the Oklahoma Center for the Advancement of Science and Technology (to Dr. Csiszar and Dr. Ungvari), the Presbyterian Health Foundation (to Dr. Unvari and Dr. Csiszar), the National Institute on Aging?supported Geroscience Training Program in Oklahoma (T32AG052363), and the Cellular and Molecular GeroScience CoBRE (1P20GM125528). The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2020 American College of Cardiology Foundation",
year = "2020",
month = mar,
day = "3",
doi = "10.1016/j.jacc.2019.11.061",
language = "English (US)",
volume = "75",
pages = "931--941",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "8",
}