Mechanisms underlying cross-orientation suppression in cat visual cortex

Nicholas J. Priebe, David Ferster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

In simple cells of the cat primary visual cortex, null-oriented stimuli, which by themselves evoke no response, can completely suppress the spiking response to optimally oriented stimuli. This cross-orientation suppression has been interpreted as evidence for cross-orientation inhibition: synaptic inhibition among cortical cells with different preferred orientations. In intracellular recordings from simple cells, however, we found that cross-oriented stimuli suppressed, rather than enhanced, synaptic inhibition and, at the same time, suppressed synaptic excitation. Much of the suppression of excitation could be accounted for by the behavior of geniculate relay cells: contrast saturation and rectification in relay cell responses, when applied to a linear feed-forward model, predicted cross-orientation suppression of the modulation (F1) component of excitation evoked in simple cells. In addition, we found that the suppression of the spike output of simple cells was almost twice the suppression of their synaptic inputs. Thus, cross-orientation suppression, like orientation selectivity, is strongly amplified by threshold.

Original languageEnglish (US)
Pages (from-to)552-561
Number of pages10
JournalNature neuroscience
Volume9
Issue number4
DOIs
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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