Mechanisms underlying mast cell influence on EAE disease course

Melissa A. Brown*, Melinda B. Tanzola, Michaela Robbie-Ryan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

It is well established that CD4+ T cells are of central importance in mediating the autoimmune destruction associated with the neurological demyelinating disease Multiple sclerosis (MS) and the rodent model of MS, EAE (experimental allergic encephalomyelitis). However, other cells also play a critical role in the inflammatory events that lead to the varying degrees of myelin and axonal damage observed in this disease syndrome. In this review, we present evidence that mast cells, best studied in the context of allergic disease, contribute to EAE disease pathology. Using mast cell-deficient mice, we demonstrate that mast cells are necessary for the full manifestation of MOG-induced EAE disease and show that cross-linking of Fc receptors is one mechanism of mast cell activation in disease. In addition, we provide evidence that mast cells exert influences outside the CNS, perhaps through the effects on the generation of the anti-MOG T cell response.

Original languageEnglish (US)
Pages (from-to)1373-1378
Number of pages6
JournalMolecular Immunology
Volume38
Issue number16-18
DOIs
StatePublished - 2002

Keywords

  • Autoimmunity
  • CNS
  • EAE disease
  • Fc receptors
  • Mast cell-deficient mice
  • Mast cells
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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