Abstract
Mechanized silica nanoparticles, equipped with pillar[5]arene-[2] pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading, cargo charge-type does not appear to have any significant influence on the amount of cargo loading or its release. These findings open up the possibility of using pillar[n]arene and its derivatives for the formation of robust and dynamic nanosystems that are capable of performing useful functions.
Original language | English (US) |
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Pages (from-to) | 3224-3229 |
Number of pages | 6 |
Journal | Small |
Volume | 9 |
Issue number | 19 |
DOIs | |
State | Published - Oct 11 2013 |
Keywords
- cargo release
- drug delivery
- pillar[n]enes
- silica nanoparticles
ASJC Scopus subject areas
- Biotechnology
- Biomaterials
- Chemistry(all)
- Materials Science(all)