Mechanized silica nanoparticles based on pillar[5]arenes for on-command cargo release

Yu Long Sun, Ying Wei Yang*, Dai Xiong Chen, Guan Wang, Yue Zhou, Chun Yu Wang, J. Fraser Stoddart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


Mechanized silica nanoparticles, equipped with pillar[5]arene-[2] pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading, cargo charge-type does not appear to have any significant influence on the amount of cargo loading or its release. These findings open up the possibility of using pillar[n]arene and its derivatives for the formation of robust and dynamic nanosystems that are capable of performing useful functions.

Original languageEnglish (US)
Pages (from-to)3224-3229
Number of pages6
Issue number19
StatePublished - Oct 11 2013


  • cargo release
  • drug delivery
  • pillar[n]enes
  • silica nanoparticles

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Biotechnology
  • Biomaterials


Dive into the research topics of 'Mechanized silica nanoparticles based on pillar[5]arenes for on-command cargo release'. Together they form a unique fingerprint.

Cite this