Mechanized silica nanoparticles based on pillar[5]arenes for on-command cargo release

Yu Long Sun; Ying Wei Yang; Dai Xiong Chen; Guan Wang; Yue Zhou; Chun Yu Wang; J. Fraser Stoddart

doi:10.1002/smll.201300445

Mechanized silica nanoparticles based on pillar[5]arenes for on-command cargo release

Yu Long Sun, Ying Wei Yang^*, Dai Xiong Chen, Guan Wang, Yue Zhou, Chun Yu Wang, J. Fraser Stoddart

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Mechanized silica nanoparticles, equipped with pillar[5]arene-[2] pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading, cargo charge-type does not appear to have any significant influence on the amount of cargo loading or its release. These findings open up the possibility of using pillar[n]arene and its derivatives for the formation of robust and dynamic nanosystems that are capable of performing useful functions.

Original language	English (US)
Pages (from-to)	3224-3229
Number of pages	6
Journal	Small
Volume	9
Issue number	19
DOIs	https://doi.org/10.1002/smll.201300445
State	Published - Oct 11 2013

Keywords

cargo release
drug delivery
pillar[n]enes
silica nanoparticles

ASJC Scopus subject areas

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

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10.1002/smll.201300445

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AU - Stoddart, J. Fraser

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Mechanized silica nanoparticles based on pillar[5]arenes for on-command cargo release

Abstract

Keywords

ASJC Scopus subject areas

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