Mechano-active tissue scaffold system based on a magnetic nanoparticle embedded nanofibrous membrane

Sheng Po Fang, Hulan Shang, Pit Fee Jao, Kyoung Tae Kim, Gloria J. Kim, Jung H. Yoon, Kun Cho, Adam J. Katz, Yong Kyu Y K Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A mechano-active nanofibrous scaffold system for in vitro active cell culture is fabricated and demonstrated using electrospun nanofibers with magnetic nanoparticles embedded, and an electromagnet. The electrospun nanofiber consists of polycaprolactone and iron oxide nanoparticles. The magnetic nanofibrous membrane is held by micromachined printing circuit board (PCB) O-rings and remotely actuated by an electromagnet, which generates alternating current (AC) magnetic fields. The scaffold provides mechanical stress and strain on culturing cells in response to external AC magnetic fields. The mechanical properties of the magnetic nanoporous membrane including the density, porosity, and effective Young's modulus are characterized. Cell viabilities on the nanofibrous membrane with and without magnetic nanoparticles embedded have been tested.

Original languageEnglish (US)
Title of host publicationMEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages917-920
Number of pages4
ISBN (Print)9781479935086
DOIs
StatePublished - 2014
Event27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States
Duration: Jan 26 2014Jan 30 2014

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
CountryUnited States
CitySan Francisco, CA
Period1/26/141/30/14

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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