Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks

Dong Hyun Kim; Pavel Karavayev; Elena A. Rozhkova; John Pearson; Volodymyr Yefremenko; Samuel D. Bader; Valentyn Novosad

doi:10.1039/c1jm10272a

Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks

Dong Hyun Kim, Pavel Karavayev, Elena A. Rozhkova, John Pearson, Volodymyr Yefremenko, Samuel D. Bader, Valentyn Novosad

Radiology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We report a doxorubicin loaded chitosan biopolymer-ferromagnetic disks hybrid system capable of on-demand magnetomechanically induced release of drug molecules. Gold covered ferromagnetic disks were encapsulated into the polymer scaffold through the assembly of the thiolated chitosan on the disk's gold surface followed by entrapping of the doxorubicin drug within a cross-linked polymer matrix. We demonstrate that the release process can be effectively tuned and controlled by varying the magnetic field characteristics: orientation, amplitude, frequency and duration.

Original language	English (US)
Pages (from-to)	8422-8426
Number of pages	5
Journal	Journal of Materials Chemistry
Volume	21
Issue number	23
DOIs	https://doi.org/10.1039/c1jm10272a
State	Published - Jun 21 2011

ASJC Scopus subject areas

General Chemistry
Materials Chemistry

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10.1039/c1jm10272a

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abstract = "We report a doxorubicin loaded chitosan biopolymer-ferromagnetic disks hybrid system capable of on-demand magnetomechanically induced release of drug molecules. Gold covered ferromagnetic disks were encapsulated into the polymer scaffold through the assembly of the thiolated chitosan on the disk's gold surface followed by entrapping of the doxorubicin drug within a cross-linked polymer matrix. We demonstrate that the release process can be effectively tuned and controlled by varying the magnetic field characteristics: orientation, amplitude, frequency and duration.",

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AU - Kim, Dong Hyun

AU - Karavayev, Pavel

AU - Rozhkova, Elena A.

AU - Pearson, John

AU - Yefremenko, Volodymyr

AU - Bader, Samuel D.

AU - Novosad, Valentyn

PY - 2011/6/21

Y1 - 2011/6/21

N2 - We report a doxorubicin loaded chitosan biopolymer-ferromagnetic disks hybrid system capable of on-demand magnetomechanically induced release of drug molecules. Gold covered ferromagnetic disks were encapsulated into the polymer scaffold through the assembly of the thiolated chitosan on the disk's gold surface followed by entrapping of the doxorubicin drug within a cross-linked polymer matrix. We demonstrate that the release process can be effectively tuned and controlled by varying the magnetic field characteristics: orientation, amplitude, frequency and duration.

AB - We report a doxorubicin loaded chitosan biopolymer-ferromagnetic disks hybrid system capable of on-demand magnetomechanically induced release of drug molecules. Gold covered ferromagnetic disks were encapsulated into the polymer scaffold through the assembly of the thiolated chitosan on the disk's gold surface followed by entrapping of the doxorubicin drug within a cross-linked polymer matrix. We demonstrate that the release process can be effectively tuned and controlled by varying the magnetic field characteristics: orientation, amplitude, frequency and duration.

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Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks

Abstract

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