Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks

Dong Hyun Kim, Pavel Karavayev, Elena A. Rozhkova, John Pearson, Volodymyr Yefremenko, Samuel D. Bader, Valentyn Novosad

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We report a doxorubicin loaded chitosan biopolymer-ferromagnetic disks hybrid system capable of on-demand magnetomechanically induced release of drug molecules. Gold covered ferromagnetic disks were encapsulated into the polymer scaffold through the assembly of the thiolated chitosan on the disk's gold surface followed by entrapping of the doxorubicin drug within a cross-linked polymer matrix. We demonstrate that the release process can be effectively tuned and controlled by varying the magnetic field characteristics: orientation, amplitude, frequency and duration.

Original languageEnglish (US)
Pages (from-to)8422-8426
Number of pages5
JournalJournal of Materials Chemistry
Volume21
Issue number23
DOIs
StatePublished - Jun 21 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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    Kim, D. H., Karavayev, P., Rozhkova, E. A., Pearson, J., Yefremenko, V., Bader, S. D., & Novosad, V. (2011). Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks. Journal of Materials Chemistry, 21(23), 8422-8426. https://doi.org/10.1039/c1jm10272a