TY - JOUR
T1 - Medial prefrontal and subcortical mechanisms underlying the acquisition of motor and cognitive action sequences in humans
AU - Koechlin, Etienne
AU - Danek, Adrian
AU - Burnod, Yves
AU - Grafman, Jordan
PY - 2002/7/18
Y1 - 2002/7/18
N2 - The anterior medial prefrontal cortex (AMPC) in humans is involved in affect and in regulating goal-directed behaviors. The precise function of the AMPC, however, is poorly understood. Using magnetic resonance imaging, we found that bilateral regions in the AMPC were selectively recruited to compute the reliability of subjects' expectations that developed when subjects were learning sequences of cognitive tasks. In contrast, regions similarly recruited in learning sequences of motor acts were found in the ventral striatum. Our results show that beyond the execution of motor acts, the AMPC is selectively engaged in computing the relevance of cognitive goals that subjects intend to achieve. This indicates that the fronto-striatal circuit, including the ventral striatum and AMPC, subserves hierarchically distinct evaluative processes mediating the human ability to build behavioral plans, ranging from motor to cognitive action plans.
AB - The anterior medial prefrontal cortex (AMPC) in humans is involved in affect and in regulating goal-directed behaviors. The precise function of the AMPC, however, is poorly understood. Using magnetic resonance imaging, we found that bilateral regions in the AMPC were selectively recruited to compute the reliability of subjects' expectations that developed when subjects were learning sequences of cognitive tasks. In contrast, regions similarly recruited in learning sequences of motor acts were found in the ventral striatum. Our results show that beyond the execution of motor acts, the AMPC is selectively engaged in computing the relevance of cognitive goals that subjects intend to achieve. This indicates that the fronto-striatal circuit, including the ventral striatum and AMPC, subserves hierarchically distinct evaluative processes mediating the human ability to build behavioral plans, ranging from motor to cognitive action plans.
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U2 - 10.1016/S0896-6273(02)00742-0
DO - 10.1016/S0896-6273(02)00742-0
M3 - Article
C2 - 12160754
AN - SCOPUS:0037130475
SN - 0896-6273
VL - 35
SP - 371
EP - 381
JO - Neuron
JF - Neuron
IS - 2
ER -