Medical therapy for inflammatory bowel disease

R. B. Stein*, S. B. Hanauer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Despite advances in our understanding of Crohn's disease and ulcerative colitis, the origins of the inflammatory bowel diseases (IBD) remain elusive. The armamentarium of therapeutic modalities used in the treatment of Crohn's disease and ulcerative colitis works at various sites along the immunoinflammatory cascades. This article reviews the pharmacology, mechanisms of action, clinical efficacy, and adverse effects of traditional therapies, such as aminosalicylates and corticosteroids, and examines the expanding number of immunomodulatory agents used in the management of IBD.

Original languageEnglish (US)
Pages (from-to)297-321
Number of pages25
JournalGastroenterology Clinics of North America
Volume28
Issue number2
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Gastroenterology

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