TY - JOUR
T1 - Medical therapy for inflammatory bowel disease
AU - Stein, R. B.
AU - Hanauer, S. B.
PY - 1999
Y1 - 1999
N2 - Despite advances in our understanding of Crohn's disease and ulcerative colitis, the origins of the inflammatory bowel diseases (IBD) remain elusive. The armamentarium of therapeutic modalities used in the treatment of Crohn's disease and ulcerative colitis works at various sites along the immunoinflammatory cascades. This article reviews the pharmacology, mechanisms of action, clinical efficacy, and adverse effects of traditional therapies, such as aminosalicylates and corticosteroids, and examines the expanding number of immunomodulatory agents used in the management of IBD.
AB - Despite advances in our understanding of Crohn's disease and ulcerative colitis, the origins of the inflammatory bowel diseases (IBD) remain elusive. The armamentarium of therapeutic modalities used in the treatment of Crohn's disease and ulcerative colitis works at various sites along the immunoinflammatory cascades. This article reviews the pharmacology, mechanisms of action, clinical efficacy, and adverse effects of traditional therapies, such as aminosalicylates and corticosteroids, and examines the expanding number of immunomodulatory agents used in the management of IBD.
UR - http://www.scopus.com/inward/record.url?scp=0032980138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032980138&partnerID=8YFLogxK
U2 - 10.1016/S0889-8553(05)70058-3
DO - 10.1016/S0889-8553(05)70058-3
M3 - Article
C2 - 10372270
AN - SCOPUS:0032980138
SN - 0889-8553
VL - 28
SP - 297
EP - 321
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 2
ER -