MEDICI: Mining essentiality data to identify critical interactions for cancer drug target discovery and development

Keyphrases

• Protein-protein Interaction 100%
• Medici 100%
• Drug Target Discovery 100%
• Cancer Drug Targets 100%
• Therapeutic Development 8%
• Lung Cancer Patients 8%
• Overall Survival 8%
• Cell Proliferation 8%
• Genetic mutation 8%
• Specificity Protein 1 8%
• Freely Available 8%
• Computational Methods 8%
• Drug Discovery 8%
• New Targets 8%
• Endogenous Protein 8%
• Cancer Biology 8%
• Anticancer Therapeutics 8%
• Gene Silencing 8%
• Network Model 8%
• Understanding of Cancer 8%
• Oncogenic Signaling 8%
• Therapeutic Discovery 8%
• Gene Knockout 8%
• Analytic Framework 8%
• Cellular Survival 8%
• Network Topology 8%
• Interaction Pathway 8%
• Protein Essentiality 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Drug Discovery 33%
• Overall Survival 33%
• Lung Cancer 33%
• Carcinogenesis 33%

Biochemistry, Genetics and Molecular Biology

• Protein-Protein Interaction 100%
• Anticancer 9%
• Gene Mutation 9%
• Cell Proliferation 9%
• Cell Survival 9%
• Overall Survival 9%
• Protein Interaction 9%
• Gene Knockdown 9%
• Gene Inactivation 9%
• Carcinogenesis 9%