MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex

Dana Leifer; Dimitri Krainc; Yie Teh Yu; John Mcdermott; Roger E. Breitbart; John Heng; Rachael L. Neve; Barry Kosofsky; Bernardo Nadal-Ginard; Stuart A. Lipton

doi:10.1073/pnas.90.4.1546

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex

Dana Leifer, Dimitri Krainc, Yie Teh Yu, John Mcdermott, Roger E. Breitbart, John Heng, Rachael L. Neve, Barry Kosofsky, Bernardo Nadal-Ginard, Stuart A. Lipton

Neurology

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.

Original language	English (US)
Pages (from-to)	1546-1550
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	90
Issue number	4
DOIs	https://doi.org/10.1073/pnas.90.4.1546
State	Published - 1993

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Leifer, D., Krainc, D., Yu, Y. T., Mcdermott, J., Breitbart, R. E., Heng, J., Neve, R. L., Kosofsky, B., Nadal-Ginard, B., & Lipton, S. A. (1993). MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America, 90(4), 1546-1550. https://doi.org/10.1073/pnas.90.4.1546

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title = "MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex",

abstract = "We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.",

author = "Dana Leifer and Dimitri Krainc and Yu, {Yie Teh} and John Mcdermott and Breitbart, {Roger E.} and John Heng and Neve, {Rachael L.} and Barry Kosofsky and Bernardo Nadal-Ginard and Lipton, {Stuart A.}",

year = "1993",

doi = "10.1073/pnas.90.4.1546",

language = "English (US)",

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Leifer, D, Krainc, D, Yu, YT, Mcdermott, J, Breitbart, RE, Heng, J, Neve, RL, Kosofsky, B, Nadal-Ginard, B & Lipton, SA 1993, 'MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex', Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 4, pp. 1546-1550. https://doi.org/10.1073/pnas.90.4.1546

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T1 - MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex

AU - Leifer, Dana

AU - Krainc, Dimitri

AU - Yu, Yie Teh

AU - Mcdermott, John

AU - Breitbart, Roger E.

AU - Heng, John

AU - Neve, Rachael L.

AU - Kosofsky, Barry

AU - Nadal-Ginard, Bernardo

AU - Lipton, Stuart A.

PY - 1993

Y1 - 1993

N2 - We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.

AB - We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.

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JO - Proceedings of the National Academy of Sciences of the United States of America

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MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex

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