Megestrol acetate for treatment of cachexia associated with human immunodeficiency virus (HIV) infection

J. H. Von Roenn, R. L. Murphy, K. M. Weber, L. M. Williams, S. A. Weitzman

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Cachexia is a common problem in patients infected with human immunodeficiency virus (HIV) and predicts a poor prognosis. The deleterious effects of malnutrition on immunity to infection are well recognized. Therefore, evaluation of nutritional status and treatment, if indicated, in persons with HIV infection may be particularly important. Recently, megestrol acetate, a synthetic orally active progesterone widely used for the therapy of advanced breast cancer, was reported to stimulate the appetite and produce weight gain. On the basis of this information, we initiated megestrol acetate therapy in persons with HIV infection and severe anorexia and weight loss to evaluate its tolerability and potential benefits.

Original languageEnglish (US)
Pages (from-to)840-841
Number of pages2
JournalAnnals of internal medicine
Volume109
Issue number10
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Internal Medicine

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