Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities

Zeynep Eroglu, Sheri L. Holmen, Qing Chen, Nikhil I. Khushalani, Ravi Amaravadi, Reena Thomas, Kamran A. Ahmed, Hussein Tawbi, Sunandana Chandra, Joseph Markowitz, Inna Smalley, James K.C. Liu, Yian Ann Chen, Yana G. Najjar, Florian A. Karreth, Daniel Abate-Daga, Isabella C. Glitza, Jeffrey Alan Sosman, Vernon K. Sondak, Marcus Bosenberg & 7 others Meenhard Herlyn, Michael B. Atkins, Harriet Kluger, Kim Margolin, Peter A. Forsyth, Michael A. Davies, Keiran S.M. Smalley

Research output: Contribution to journalArticle

Abstract

In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System (CNS) Metastases in Tampa, Florida. In this white paper, we outline the current status of basic science, translational, and clinical research into melanoma brain metastasis development and therapeutic management. We further outline the important challenges that remain for the field and the critical barriers that need to be overcome for continued progress to be made in this clinically difficult area.

Original languageEnglish (US)
Pages (from-to)458-469
Number of pages12
JournalPigment Cell and Melanoma Research
Volume32
Issue number3
DOIs
StatePublished - May 1 2019

Fingerprint

Neurology
Melanoma
Central Nervous System
Neoplasm Metastasis
Brain
Translational Medical Research
Research
Neoplasms
Therapeutics

Keywords

  • brain metastases
  • immunotherapy
  • melanoma
  • metastasis
  • targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

Cite this

Eroglu, Z., Holmen, S. L., Chen, Q., Khushalani, N. I., Amaravadi, R., Thomas, R., ... Smalley, K. S. M. (2019). Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities. Pigment Cell and Melanoma Research, 32(3), 458-469. https://doi.org/10.1111/pcmr.12771
Eroglu, Zeynep ; Holmen, Sheri L. ; Chen, Qing ; Khushalani, Nikhil I. ; Amaravadi, Ravi ; Thomas, Reena ; Ahmed, Kamran A. ; Tawbi, Hussein ; Chandra, Sunandana ; Markowitz, Joseph ; Smalley, Inna ; Liu, James K.C. ; Chen, Yian Ann ; Najjar, Yana G. ; Karreth, Florian A. ; Abate-Daga, Daniel ; Glitza, Isabella C. ; Sosman, Jeffrey Alan ; Sondak, Vernon K. ; Bosenberg, Marcus ; Herlyn, Meenhard ; Atkins, Michael B. ; Kluger, Harriet ; Margolin, Kim ; Forsyth, Peter A. ; Davies, Michael A. ; Smalley, Keiran S.M. / Melanoma central nervous system metastases : An update to approaches, challenges, and opportunities. In: Pigment Cell and Melanoma Research. 2019 ; Vol. 32, No. 3. pp. 458-469.
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Eroglu, Z, Holmen, SL, Chen, Q, Khushalani, NI, Amaravadi, R, Thomas, R, Ahmed, KA, Tawbi, H, Chandra, S, Markowitz, J, Smalley, I, Liu, JKC, Chen, YA, Najjar, YG, Karreth, FA, Abate-Daga, D, Glitza, IC, Sosman, JA, Sondak, VK, Bosenberg, M, Herlyn, M, Atkins, MB, Kluger, H, Margolin, K, Forsyth, PA, Davies, MA & Smalley, KSM 2019, 'Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities' Pigment Cell and Melanoma Research, vol. 32, no. 3, pp. 458-469. https://doi.org/10.1111/pcmr.12771

Melanoma central nervous system metastases : An update to approaches, challenges, and opportunities. / Eroglu, Zeynep; Holmen, Sheri L.; Chen, Qing; Khushalani, Nikhil I.; Amaravadi, Ravi; Thomas, Reena; Ahmed, Kamran A.; Tawbi, Hussein; Chandra, Sunandana; Markowitz, Joseph; Smalley, Inna; Liu, James K.C.; Chen, Yian Ann; Najjar, Yana G.; Karreth, Florian A.; Abate-Daga, Daniel; Glitza, Isabella C.; Sosman, Jeffrey Alan; Sondak, Vernon K.; Bosenberg, Marcus; Herlyn, Meenhard; Atkins, Michael B.; Kluger, Harriet; Margolin, Kim; Forsyth, Peter A.; Davies, Michael A.; Smalley, Keiran S.M.

In: Pigment Cell and Melanoma Research, Vol. 32, No. 3, 01.05.2019, p. 458-469.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Melanoma central nervous system metastases

T2 - An update to approaches, challenges, and opportunities

AU - Eroglu, Zeynep

AU - Holmen, Sheri L.

AU - Chen, Qing

AU - Khushalani, Nikhil I.

AU - Amaravadi, Ravi

AU - Thomas, Reena

AU - Ahmed, Kamran A.

AU - Tawbi, Hussein

AU - Chandra, Sunandana

AU - Markowitz, Joseph

AU - Smalley, Inna

AU - Liu, James K.C.

AU - Chen, Yian Ann

AU - Najjar, Yana G.

AU - Karreth, Florian A.

AU - Abate-Daga, Daniel

AU - Glitza, Isabella C.

AU - Sosman, Jeffrey Alan

AU - Sondak, Vernon K.

AU - Bosenberg, Marcus

AU - Herlyn, Meenhard

AU - Atkins, Michael B.

AU - Kluger, Harriet

AU - Margolin, Kim

AU - Forsyth, Peter A.

AU - Davies, Michael A.

AU - Smalley, Keiran S.M.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System (CNS) Metastases in Tampa, Florida. In this white paper, we outline the current status of basic science, translational, and clinical research into melanoma brain metastasis development and therapeutic management. We further outline the important challenges that remain for the field and the critical barriers that need to be overcome for continued progress to be made in this clinically difficult area.

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KW - brain metastases

KW - immunotherapy

KW - melanoma

KW - metastasis

KW - targeted therapy

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DO - 10.1111/pcmr.12771

M3 - Article

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JO - Pigment Cell and Melanoma Research

JF - Pigment Cell and Melanoma Research

SN - 1755-1471

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