Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities

Zeynep Eroglu*, Sheri L. Holmen, Qing Chen, Nikhil I. Khushalani, Ravi Amaravadi, Reena Thomas, Kamran A. Ahmed, Hussein Tawbi, Sunandana Chandra, Joseph Markowitz, Inna Smalley, James K.C. Liu, Yian Ann Chen, Yana G. Najjar, Florian A. Karreth, Daniel Abate-Daga, Isabella C. Glitza, Jeffrey A. Sosman, Vernon K. Sondak, Marcus BosenbergMeenhard Herlyn, Michael B. Atkins, Harriet Kluger, Kim Margolin, Peter A. Forsyth, Michael A. Davies, Keiran S.M. Smalley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System (CNS) Metastases in Tampa, Florida. In this white paper, we outline the current status of basic science, translational, and clinical research into melanoma brain metastasis development and therapeutic management. We further outline the important challenges that remain for the field and the critical barriers that need to be overcome for continued progress to be made in this clinically difficult area.

Original languageEnglish (US)
Pages (from-to)458-469
Number of pages12
JournalPigment Cell and Melanoma Research
Issue number3
StatePublished - May 2019


  • brain metastases
  • immunotherapy
  • melanoma
  • metastasis
  • targeted therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology
  • Oncology


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