Melanoma driver mutations and immune therapy

Douglas B. Johnson*, Christine M. Lovly, Ryan J. Sullivan, Richard D. Carvajal, Jeffrey A. Sosman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Melanoma harbors recurrent oncogenic driver mutations in BRAF and NRAS, but these mutations’ impact on immunotherapy outcomes is unclear. We assessed 229 patients treated with immunotherapy, and found that clinical outcomes were largely superior in those with NRAS mutations. Herein, we discuss our findings and their implications for melanoma therapeutics.

Original languageEnglish (US)
Article numbere1051299
JournalOncoImmunology
Volume5
Issue number5
DOIs
StatePublished - May 3 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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