Melanoma tumor cell heterogeneity: A molecular approach to study subpopulations expressing the embryonic morphogen nodal

Elisabeth A. Seftor, Richard E B Seftor, Don S. Weldon, Gina Kirsammer, Naira V. Margaryan, Alina Gilgur, Mary J C Hendrix*

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

As the frequency of melanoma increases, current treatment strategies are struggling to significantly impact patient survival. One of the critical issues in designing efficient therapies is understanding the composition of heterogeneous melanoma tumors in order to target cancer stem cells (CSCs) and drug-resistant subpopulations. In this review, we summarize recent findings pertinent to the reemergence of the embryonic Nodal signaling pathway in melanoma and its significance as a prognostic biomarker and therapeutic target. In addition, we offer a novel molecular approach to studying the functional relevance of Nodal-expressing subpopulations and their CSC phenotype.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalSeminars in Oncology
Volume41
Issue number2
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Hematology
  • Oncology

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