Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits

Takuma Sonoda, Seul Ki Lee, Lutz Birnbaumer, Tiffany M. Schmidt*

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Melanopsin is expressed in distinct types of intrinsically photosensitive retinal ganglion cells (ipRGCs), which drive behaviors from circadian photoentrainment to contrast detection. A major unanswered question is how the same photopigment, melanopsin, influences such vastly different functions. Here we show that melanopsin's role in contrast detection begins in the retina, via direct effects on M4 ipRGC (ON alpha RGC) signaling. This influence persists across an unexpectedly wide range of environmental light levels ranging from starlight to sunlight, which considerably expands the functional reach of melanopsin on visual processing. Moreover, melanopsin increases the excitability of M4 ipRGCs via closure of potassium leak channels, a previously unidentified target of the melanopsin phototransduction cascade. Strikingly, this mechanism is selective for image-forming circuits, as M1 ipRGCs (involved in non-image forming behaviors), exhibit a melanopsin-mediated decrease in excitability. Thus, melanopsin signaling is repurposed by ipRGC subtypes to shape distinct visual behaviors. Sonoda et al. identify leak potassium channels as the major target of melanopsin phototransduction in M4 ipRGCs/ON alpha retinal ganglion cells. Melanopsin-dependent closure of these channels enhances cell excitability and contrast sensitivity across a wide range of light intensities.

Original languageEnglish (US)
Pages (from-to)754-767.e4
JournalNeuron
Volume99
Issue number4
DOIs
StatePublished - Aug 22 2018

ASJC Scopus subject areas

  • Neuroscience(all)

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