Melanopsin-positive intrinsically photosensitive retinal ganglion cells: From form to function

Tiffany M. Schmidt, Michael Tri H Do, Dennis Dacey, Robert Lucas, Samer Hattar, Anna Matynia*

*Corresponding author for this work

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

Melanopsin imparts an intrinsic photosensitivity to a subclass of retinal ganglion cells (ipRGCs). Generally thought of as irradiance detectors, ipRGCs target numerous brain regions involved in non-image-forming vision. ipRGCs integrate their intrinsic, melanopsinmediated light information with rod/cone signals relayed via synaptic connections to influence light-dependent behaviors. Early observations indicated diversity among these cells and recently several specific subtypes have been identified. These subtypes differ in morphological and physiological form, controlling separate functions that range from biological rhythm via circadian photoentrainment, to protective behavioral responses including pupil constriction and light avoidance, and even image-forming vision. In this Mini-Symposium review, we will discuss some recent findings that highlight the diversity in both form and function of these recently discovered atypical photoreceptors.

Original languageEnglish (US)
Pages (from-to)16094-16101
Number of pages8
JournalJournal of Neuroscience
Volume31
Issue number45
DOIs
StatePublished - Nov 9 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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