Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs

Herbert Y. Meltzer*, James I. Koenig, J. Frank Nash, Gary A. Gudelsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The effects of atypical neuroleptics within the neuroendocrine axis of rodents can be distinguished from those of typical neuroleptics by the production of: 1) a shortlived increase in serum PRL concentrations, 2) an acute increase in the activity of TIDA neurons, and 3) a marked increase in serum corticosterone concentrations. It is of interest to specculate that the pharmacological properties of atypical neuroleptics which mediate the unique neuroendocrine responses are of relevance to an understanding of the mechanisms which underlie the clinical profile of these antipsychotic agents.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalActa Psychiatrica Scandinavica
Volume80
Issue number352 S
DOIs
StatePublished - Aug 1989

Keywords

  • atypical neuroleptics
  • clozapine
  • melperone
  • prolactin

ASJC Scopus subject areas

  • Psychiatry and Mental health

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