Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs

Herbert Y. Meltzer; James I. Koenig; J. Frank Nash; Gary A. Gudelsky

doi:10.1111/j.1600-0447.1989.tb06432.x

Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs

Herbert Y. Meltzer^*, James I. Koenig, J. Frank Nash, Gary A. Gudelsky

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The effects of atypical neuroleptics within the neuroendocrine axis of rodents can be distinguished from those of typical neuroleptics by the production of: 1) a shortlived increase in serum PRL concentrations, 2) an acute increase in the activity of TIDA neurons, and 3) a marked increase in serum corticosterone concentrations. It is of interest to specculate that the pharmacological properties of atypical neuroleptics which mediate the unique neuroendocrine responses are of relevance to an understanding of the mechanisms which underlie the clinical profile of these antipsychotic agents.

Original language	English (US)
Pages (from-to)	24-29
Number of pages	6
Journal	Acta Psychiatrica Scandinavica
Volume	80
Issue number	352 S
DOIs	https://doi.org/10.1111/j.1600-0447.1989.tb06432.x
State	Published - Aug 1989

Keywords

atypical neuroleptics
clozapine
melperone
prolactin

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0447.1989.tb06432.x

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title = "Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs",

abstract = "The effects of atypical neuroleptics within the neuroendocrine axis of rodents can be distinguished from those of typical neuroleptics by the production of: 1) a shortlived increase in serum PRL concentrations, 2) an acute increase in the activity of TIDA neurons, and 3) a marked increase in serum corticosterone concentrations. It is of interest to specculate that the pharmacological properties of atypical neuroleptics which mediate the unique neuroendocrine responses are of relevance to an understanding of the mechanisms which underlie the clinical profile of these antipsychotic agents.",

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T2 - neuroendocrine effects of atypical neuroleptic drugs

AU - Meltzer, Herbert Y.

AU - Koenig, James I.

AU - Nash, J. Frank

AU - Gudelsky, Gary A.

PY - 1989/8

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N2 - The effects of atypical neuroleptics within the neuroendocrine axis of rodents can be distinguished from those of typical neuroleptics by the production of: 1) a shortlived increase in serum PRL concentrations, 2) an acute increase in the activity of TIDA neurons, and 3) a marked increase in serum corticosterone concentrations. It is of interest to specculate that the pharmacological properties of atypical neuroleptics which mediate the unique neuroendocrine responses are of relevance to an understanding of the mechanisms which underlie the clinical profile of these antipsychotic agents.

AB - The effects of atypical neuroleptics within the neuroendocrine axis of rodents can be distinguished from those of typical neuroleptics by the production of: 1) a shortlived increase in serum PRL concentrations, 2) an acute increase in the activity of TIDA neurons, and 3) a marked increase in serum corticosterone concentrations. It is of interest to specculate that the pharmacological properties of atypical neuroleptics which mediate the unique neuroendocrine responses are of relevance to an understanding of the mechanisms which underlie the clinical profile of these antipsychotic agents.

KW - atypical neuroleptics

KW - clozapine

KW - melperone

KW - prolactin

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ER -

Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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