Memantine-Induced chorea and dystonia

Letizia Goncalves Borges*, Borna Bonakdarpour

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Memantine is an uncompetitive N-methyl-Daspartate receptor antagonist and probably also has an indirect dopaminergic action at high concentrations. We describe a person with Alzheimer’s disease who developed chorea and dystonia after inadvertently doubling of her daily dose by taking extended-release (XR) memantine twice daily, rather than once daily (planned dose memantine XR, 21 mg once daily), after the drug was switched from immediate release (IR, 10 mg twice daily). Memantine is rarely associated with movement disorders, but this case emphasises the need for awareness of potential problems when switching from memantine IR to XR.

Original languageEnglish (US)
Pages (from-to)133-134
Number of pages2
JournalPractical Neurology
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2017

ASJC Scopus subject areas

  • Clinical Neurology

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