Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression

Isidora Petrović*, Nataša Kovačević Grujičić, Jelena Popović, A. Krstić, Milena Milivojević, Milena Stevanović

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal™ TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene.

Original languageEnglish (US)
Pages (from-to)517-525
Number of pages9
JournalArchives of Biological Sciences
Volume63
Issue number3
DOIs
StatePublished - 2011

Keywords

  • AP-1
  • Angiogenesis
  • CREB/ATF
  • SOX18

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences

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