Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

Jannik Bruun Larsen, Martin Borch Jensen, Vikram K. Bhatia, Søren L. Pedersen, Thomas Bjørnholm, Lars Iversen, Mark Uline, Igal Szleifer, Knud J. Jensen, Nikos S. Hatzakis, Dimitrios Stamou*

*Corresponding author for this work

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

Original languageEnglish (US)
Pages (from-to)192-194
Number of pages3
JournalNature Chemical Biology
Volume11
Issue number3
DOIs
StatePublished - Mar 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjørnholm, T., Iversen, L., Uline, M., Szleifer, I., Jensen, K. J., Hatzakis, N. S., & Stamou, D. (2015). Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. Nature Chemical Biology, 11(3), 192-194. https://doi.org/10.1038/nchembio.1733