@article{bf144e1fb548434693dd0c746b93c7ad,
title = "Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases",
abstract = "Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.",
author = "Larsen, {Jannik Bruun} and Jensen, {Martin Borch} and Bhatia, {Vikram K.} and Pedersen, {S{\o}ren L.} and Thomas Bj{\o}rnholm and Lars Iversen and Mark Uline and Igal Szleifer and Jensen, {Knud J.} and Hatzakis, {Nikos S.} and Dimitrios Stamou",
note = "Funding Information: This work was supported by the Lundbeck Foundation Center for Biomembranes in Nanomedicine, the Danish Councils for Independent and Strategic Research, and the University of Copenhagen programs of excellence, {\textquoteleft}Single-Molecule Nanoscience{\textquoteright}, {\textquoteleft}BioScaRT{\textquoteright} and {\textquoteleft}UNIK-Synthetic Biology{\textquoteright}. I.S. would like to acknowledge support from the US National Science Foundation under grant no. CBET-1403058 and M.J.U. acknowledges support from the US National Institutes of Health under grant no. P20GM103499. Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",
year = "2015",
month = mar,
doi = "10.1038/nchembio.1733",
language = "English (US)",
volume = "11",
pages = "192--194",
journal = "Nature Chemical Biology",
issn = "1552-4450",
publisher = "Nature Publishing Group",
number = "3",
}