Membrane fusion in muscle development and repair

Alexis R. Demonbreun, Bridget H. Biersmith, Elizabeth M. McNally*

*Corresponding author for this work

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Mature skeletal muscle forms from the fusion of skeletal muscle precursor cells, myoblasts. Myoblasts fuse to other myoblasts to generate multinucleate myotubes during myogenesis, and myoblasts also fuse to other myotubes during muscle growth and repair. Proteins within myoblasts and myotubes regulate complex processes such as elongation, migration, cell adherence, cytoskeletal reorganization, membrane coalescence, and ultimately fusion. Recent studies have identified cell surface proteins, intracellular proteins, and extracellular signaling molecules required for the proper fusion of muscle. Many proteins that actively participate in myoblast fusion also coordinate membrane repair. Here we will review mammalian membrane fusion with specific attention to proteins that mediate myoblast fusion and muscle repair.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume45
DOIs
StatePublished - Sep 1 2015

Keywords

  • Development
  • Fusion
  • Membrane
  • Muscle
  • Myoblast
  • Repair

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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