TY - JOUR
T1 - Membrane Potential Synchrony in Primary Visual Cortex during Sensory Stimulation
AU - Yu, Jianing
AU - Ferster, David
N1 - Funding Information:
We thank Drs. Ilan Lampl, Nicholas J. Priebe, and Michael P. Stryker for critical reading of the manuscript. We also thank Hirofumi Ozeki and Srivatsun Sadagopan for helpful discussions. This work was supported by the National Institute of Health (R01 EY04726).
PY - 2010/12/22
Y1 - 2010/12/22
N2 - When the primary visual cortex (V1) is activated by sensory stimulation, what is the temporal correlation between the synaptic inputs to nearby neurons? This question underlies the origin of correlated activity, the mechanism of how visually evoked activity emerges and propagates in cortical circuits, and the relationship between spontaneous and evoked activity. Here, we have recorded membrane potential from pairs of V1 neurons in anesthetized cats and found that visual stimulation suppressed low-frequency membrane potential synchrony (0-10 Hz), and often increased synchrony at high frequencies (20-80 Hz). The increase in high-frequency synchrony occurred for neurons with similar orientation preferences and for neurons with different orientation preferences and occurred for a wide range of stimulus orientations. Thus, while only a subset of neurons spike in response to visual stimulation, a far larger proportion of the circuit is correlated with spiking activity through subthreshold, high-frequency synchronous activity that crosses functional domains.
AB - When the primary visual cortex (V1) is activated by sensory stimulation, what is the temporal correlation between the synaptic inputs to nearby neurons? This question underlies the origin of correlated activity, the mechanism of how visually evoked activity emerges and propagates in cortical circuits, and the relationship between spontaneous and evoked activity. Here, we have recorded membrane potential from pairs of V1 neurons in anesthetized cats and found that visual stimulation suppressed low-frequency membrane potential synchrony (0-10 Hz), and often increased synchrony at high frequencies (20-80 Hz). The increase in high-frequency synchrony occurred for neurons with similar orientation preferences and for neurons with different orientation preferences and occurred for a wide range of stimulus orientations. Thus, while only a subset of neurons spike in response to visual stimulation, a far larger proportion of the circuit is correlated with spiking activity through subthreshold, high-frequency synchronous activity that crosses functional domains.
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U2 - 10.1016/j.neuron.2010.11.027
DO - 10.1016/j.neuron.2010.11.027
M3 - Article
C2 - 21172618
AN - SCOPUS:78650239127
VL - 68
SP - 1187
EP - 1201
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 6
ER -