Membrane stretch activates a potassium channel in pig articular chondrocytes

Marco Martina, Jerzy W. Mozrzymas, Franco Vittur*

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Activity of stretch-activated potassium channels has been recorded in articular chondrocytes using patch-clamp technique. Pressure dependence is described by a sigmoidal function with a half-maximum effect at -20.5 mbar. Selectivity for potassium is demonstrated by agreement between the reversal potential measured at different [K+](o) and the prediction of Nernst equation and by block of these channels by caesium.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1329
Issue number2
DOIs
StatePublished - Oct 23 1997

Fingerprint

Cesium
Potassium Channels
Clamping devices
Patch-Clamp Techniques
Chondrocytes
Potassium
Swine
Joints
Membranes
Pressure

Keywords

  • Articular chondrocyte
  • Hypotonic shock
  • Patch clamp
  • Pig
  • Potassium ion channel
  • Stretch activation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

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abstract = "Activity of stretch-activated potassium channels has been recorded in articular chondrocytes using patch-clamp technique. Pressure dependence is described by a sigmoidal function with a half-maximum effect at -20.5 mbar. Selectivity for potassium is demonstrated by agreement between the reversal potential measured at different [K+](o) and the prediction of Nernst equation and by block of these channels by caesium.",
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Membrane stretch activates a potassium channel in pig articular chondrocytes. / Martina, Marco; Mozrzymas, Jerzy W.; Vittur, Franco.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1329, No. 2, 23.10.1997, p. 205-210.

Research output: Contribution to journalArticle

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AU - Mozrzymas, Jerzy W.

AU - Vittur, Franco

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