Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice

Catherine C. Kaczorowski, John F. Disterhoft

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits were exposed in a subset (30%) of middle-aged mice that performed below criterion on a hippocampal-dependent contextual fear conditioning task. Basal neuronal excitability was comparable in middle-aged and young mice, but learning-related modulation of the post-burst afterhyperpolarization (AHP) - a general mechanism engaged during learning - was impaired in CA1 neurons from middle-aged weak learners. Thus, modulation of neuronal excitability is critical for retention of context fear in middle-aged mice. Disruption of AHP plasticity may contribute to contextual fear deficits in middle-aged mice - a model of age-associated cognitive decline (AACD).

Original languageEnglish (US)
Pages (from-to)362-366
Number of pages5
JournalLearning and Memory
Volume16
Issue number6
DOIs
StatePublished - Jun 2009

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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