TY - JOUR
T1 - Memory disruption by electrical stimulation of substantia nigra, pars compacta
AU - Routtenberg, Aryeh
AU - Holzman, Nancy
PY - 1973
Y1 - 1973
N2 - Electrical stimulation of the substantia nigra, pars compacta, of albino rats while they were learning a simple foot shock task of withdrawal and response suppression disrupted retention of that task 24 hours after original learning. Stimulation in the reticular zone of the substantia nigra was without effect on retention performance. Stimulation through electrodes in the medial lemniscus, red nucleus, or brainstein regions surrounding the substantia nigra, pars compacta, was also ineffective. Original learning performance, measured as time to criterion, was unimpaired by the stimulation. Posttrial stimulation in the substantia nigra, pars compacta, but not in adjacent structures, also disrupted retention performance.
AB - Electrical stimulation of the substantia nigra, pars compacta, of albino rats while they were learning a simple foot shock task of withdrawal and response suppression disrupted retention of that task 24 hours after original learning. Stimulation in the reticular zone of the substantia nigra was without effect on retention performance. Stimulation through electrodes in the medial lemniscus, red nucleus, or brainstein regions surrounding the substantia nigra, pars compacta, was also ineffective. Original learning performance, measured as time to criterion, was unimpaired by the stimulation. Posttrial stimulation in the substantia nigra, pars compacta, but not in adjacent structures, also disrupted retention performance.
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U2 - 10.1126/science.181.4094.83
DO - 10.1126/science.181.4094.83
M3 - Article
C2 - 4714294
AN - SCOPUS:0015916009
SN - 0036-8075
VL - 181
SP - 83
EP - 86
JO - Science
JF - Science
IS - 4094
ER -