Memory disruption by unilateral low level, sub-seizure stimulation of the medial amygdaloid nucleus

Elaine Bresnahan*, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

In four experiments 413 male albino rats were used to evaluate memory disruption during a retention test given 24 hr after passive avoidance learning. In Experiment 1, unilateral brain stimulation of 5 μA intensity significantly disrupted retention when applied to the amygdala but not to the dorsal hippocampus. This finding of retention disruption following amygdala stimulation was further corroborated in Experiment 2, and stimulation in the medial nucleus was indicated as the primary source for the obtained disruption. In Experiment 3, epileptogenic effects of 5 μA amygdala stimulation on hippocampal activity were contraindicated. In Experiment 4, use of a finer wire electrode to study the relative importance of individual nuclear groups confirmed that stimulation of the medial amygdaloid nucleus caused retention disruption.

Original languageEnglish (US)
Pages (from-to)513-525
Number of pages13
JournalPhysiology and Behavior
Volume9
Issue number4
DOIs
StatePublished - Jan 1 1972

Keywords

  • Brain stimulation
  • EEG
  • Hippocampus
  • Medial amygdaloid nucleus
  • Memory disruption

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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