Memory improvement via slow-oscillatory stimulation during sleep in older adults

Carmen E. Westerberg*, Susan M. Florczak, Sandra Weintraub, Marek-Marsel Mesulam, Lisa Marshall, Phyllis C Zee, Ken Paller

*Corresponding author for this work

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

We examined the intriguing but controversial idea that disrupted sleep-dependent consolidation contributes to age-related memory decline. Slow-wave activity during sleep may help strengthen neural connections and provide memories with long-term stability, in which case decreased slow-wave activity in older adults could contribute to their weaker memories. One prediction from this account is that age-related memory deficits should be reduced by artificially enhancing slow-wave activity. In young adults, applying transcranial current oscillating at a slow frequency (0.75Hz) during sleep improves memory. Here, we tested whether this procedure can improve memory in older adults. In 2 sessions separated by 1week, we applied either slow-oscillatory stimulation or sham stimulation during an afternoon nap in a double-blind, crossover design. Memory tests were administered before and after sleep. A larger improvement in word-pair recall and higher slow-wave activity was observed with slow-oscillatory stimulation than with sham stimulation. This is the first demonstration that this procedure can improve memory in older adults, suggesting that declarative memory performance in older adults is partly dependent on slow-wave activity during sleep.

Original languageEnglish (US)
Pages (from-to)2577-2586
Number of pages10
JournalNeurobiology of Aging
Volume36
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • Aging
  • Declarative memory
  • Electrical stimulation
  • Slow-wave sleep

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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