Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

Biochemistry, Genetics and Molecular Biology

• Cell Death 91%
• Menadione 83%
• Cytochrome 33%
• Species 33%
• Poly ADP Ribose Polymerase 25%
• Caspase-9 16%
• Mitochondrion 16%
• Oxidative Stress 16%
• Apoptosis 8%
• Electric Potential 8%
• Alpha Oxidation 8%
• Catalase 8%
• Mediator 8%
• Glutathione 8%
• Gene Deletion 8%
• Cell Damage 8%
• Acetylcysteine 8%
• Mitochondrial Matrix 8%
• Staurosporine 8%
• Contrast 8%
• Mitochondrial Permeability Transition Pore 8%
• Protein 8%

INIS

• apoptosis 100%
• mitochondria 41%
• oxygen 33%
• cytochromes 33%
• protection 25%
• levels 16%
• compartments 16%
• oxidants 16%
• sod 16%
• genetics 8%
• proteins 8%
• matrices 8%
• death 8%
• oxidation 8%
• concentration 8%
• permeability 8%
• damage 8%
• sensors 8%
• boron chlorides 8%
• glutathione 8%
• catalase 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Cell Death 91%
• Menadione 83%
• Reactive Oxygen Metabolite 33%
• Cytochrome C 33%
• Oxidizing Agent 16%
• Caspase 9 16%
• Cyclophilin D 16%
• Protein 8%
• Catalase 8%
• Acetylcysteine 8%
• Glutathione 8%
• Staurosporine 8%
• Copper Zinc Superoxide Dismutase 8%
• Death 8%
• Antiapoptotic 8%
• Manganese Superoxide Dismutase 8%
• Mitochondrial Permeability Transition Pore 8%
• Apoptosis 8%