Abstract
Quantitative xenotropic virus assays were done in crosses made between NZB and SWR mice. Two independently segregating autosomal dominant loci (Nzv-1 and Nzv-2) determined expression of infectious xenotropic virus. Nzv-1 alone or in association with Nzv-2 was responsible for high-grade virus expression, and low titers of virus were expressed when Nzv-2 was present and Nzv-1 was absent. Virus assays on mice of the second backcross and intercross generations confirmed this finding. The virologic phenotype of individual animals was stable for up to 1 year.
Original language | English (US) |
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Pages (from-to) | 449-452 |
Number of pages | 4 |
Journal | Virology |
Volume | 83 |
Issue number | 2 |
DOIs | |
State | Published - Dec 1977 |
ASJC Scopus subject areas
- Virology