Mendelian segregation of loci controlling xenotropic virus production in NZB crosses

Syamal K. Datta, Robert S. Schwartz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Quantitative xenotropic virus assays were done in crosses made between NZB and SWR mice. Two independently segregating autosomal dominant loci (Nzv-1 and Nzv-2) determined expression of infectious xenotropic virus. Nzv-1 alone or in association with Nzv-2 was responsible for high-grade virus expression, and low titers of virus were expressed when Nzv-2 was present and Nzv-1 was absent. Virus assays on mice of the second backcross and intercross generations confirmed this finding. The virologic phenotype of individual animals was stable for up to 1 year.

Original languageEnglish (US)
Pages (from-to)449-452
Number of pages4
JournalVirology
Volume83
Issue number2
DOIs
StatePublished - Dec 1977

ASJC Scopus subject areas

  • Virology

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