Abstract
We report a case of fibrous meningioma with tyrosine-rich crystalloid in the frontal lobe of a middle-aged woman. The patient presented with a history of several years of worsening headaches and blurry vision, which progressed to include syncopal episodes and right-sided weakness. Imaging demonstrated a dural-based extra-axial mass arising from the right orbital roof and extending superiorly along the right frontal convexity causing right-to-left midline shift. The patient underwent a craniotomy and operative resection. Tumor architecture and cytology was similar to that of a Schwannian neoplasm, with spindled cells arranged in a fascicular architecture and displaying focal nuclear palisading. Immunohistochemical stains confirmed a diagnosis of fibrous meningioma. Light microscopy demonstrated extracellular deposits of eosinophilic crystalline material parallel to the spindled tumor cells, reminiscent of “tyrosine-rich” crystals described in salivary gland neoplasms. This is the third meningioma featuring tyrosine-rich crystalloid reported in the literature; we also summarize the previous 2 reports.
Original language | English (US) |
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Pages (from-to) | 157-160 |
Number of pages | 4 |
Journal | International Journal of Surgical Pathology |
Volume | 26 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 2018 |
Keywords
- crystalloid
- meningioma
- tyrosine
ASJC Scopus subject areas
- Anatomy
- Surgery
- Pathology and Forensic Medicine