TY - JOUR
T1 - Mental paper folding performance following penetrating traumatic brain injury in combat veterans
T2 - A lesion mapping study
AU - Glass, Leila
AU - Krueger, Frank
AU - Solomon, Jeffrey
AU - Raymont, Vanessa
AU - Grafman, Jordan
N1 - Funding Information:
This study was conducted by the US National Institute of Neurological Disorders and Stroke Intramural Research Program and an individual project grant (DAMD17-01-1-0675) from the US Army Medical Research and Material Command administrated by the Henry M. Jackson Foundation (Vietnam Head Injury Study Phase III: A 30-year post-injury follow-up study). It took place at the National Navy Medical Center (project number B03-043). The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defence, nor the US Government. For further information about the Vietnam Head Injury Study, contact J. G. at [email protected].
PY - 2013/7
Y1 - 2013/7
N2 - Mental paper folding is a complex measure of visuospatial ability involving a coordinated sequence of mental transformations and is often considered a measure of mental ability. The literature is inconclusive regarding the precise neural architecture that underlies performance. We combined the administration of the Armed Forces Qualification Test boxes subtest measuring mental paper folding ability, with a voxel-based lesion symptom mapping approach to identify brain regions associated with impaired mental paper folding ability. Using a large sample of subjects with penetrating traumatic brain injury and defined lesions studied over 2 time points, roughly 15 and 35 years post-injury, enabled us to answer the causal questions regarding mental paper folding impairment. Our results revealed that brain injury significantly exacerbates the decline of performance on mental paper folding tasks over time. Our study adds novel neuropsychological and neuroimaging support for parietal lobe involvement; specifically the right inferior parietal lobule (Broadmann's Area [BA] 40) and the left parahippocampal region (BAs 19, 36). Both areas were consistently associated with mental paper folding performance and demonstrate that the right parietal lobe and the left parahippocampal gyrus play an integral role in mental paper folding tasks.
AB - Mental paper folding is a complex measure of visuospatial ability involving a coordinated sequence of mental transformations and is often considered a measure of mental ability. The literature is inconclusive regarding the precise neural architecture that underlies performance. We combined the administration of the Armed Forces Qualification Test boxes subtest measuring mental paper folding ability, with a voxel-based lesion symptom mapping approach to identify brain regions associated with impaired mental paper folding ability. Using a large sample of subjects with penetrating traumatic brain injury and defined lesions studied over 2 time points, roughly 15 and 35 years post-injury, enabled us to answer the causal questions regarding mental paper folding impairment. Our results revealed that brain injury significantly exacerbates the decline of performance on mental paper folding tasks over time. Our study adds novel neuropsychological and neuroimaging support for parietal lobe involvement; specifically the right inferior parietal lobule (Broadmann's Area [BA] 40) and the left parahippocampal region (BAs 19, 36). Both areas were consistently associated with mental paper folding performance and demonstrate that the right parietal lobe and the left parahippocampal gyrus play an integral role in mental paper folding tasks.
KW - inferior parietal
KW - left hippocampal gyrus
KW - lesion analysis
KW - mental paper folding
KW - penetrating head injury
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U2 - 10.1093/cercor/bhs153
DO - 10.1093/cercor/bhs153
M3 - Article
C2 - 22669970
AN - SCOPUS:84878855249
SN - 1047-3211
VL - 23
SP - 1663
EP - 1672
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 7
ER -