MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features

Charlotte D. Eaton; Lauro Avalos; S. John Liu; Zhenhong Chen; Naomi Zakimi; Tim Casey-Clyde; Paola Bisignano; Calixto Hope G. Lucas; Erica Stevenson; Abrar Choudhury; Harish N. Vasudevan; Stephen T. Magill; Jacob S. Young; Nevan J. Krogan; Javier E. Villanueva-Meyer; Danielle L. Swaney; David R. Raleigh

doi:10.1038/s41467-024-52284-8

Merlin^S13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features

Charlotte D. Eaton, Lauro Avalos, S. John Liu, Zhenhong Chen, Naomi Zakimi, Tim Casey-Clyde, Paola Bisignano, Calixto Hope G. Lucas, Erica Stevenson, Abrar Choudhury, Harish N. Vasudevan, Stephen T. Magill, Jacob S. Young, Nevan J. Krogan, Javier E. Villanueva-Meyer, Danielle L. Swaney, David R. Raleigh^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The molecular mechanisms underlying merlin-intact meningioma growth remain to be explored. Here, the authors show that merlin activates Wnt signalling and tumour growth through its dephosphorylation on serine 13 attenuating the inhibitory interactions with β-catenin.

Original language	English (US)
Article number	7873
Journal	Nature communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-52284-8
State	Published - Dec 2024

Funding

The authors thank Ken Probst and Noel Sirivansanti for Illustrations and Kyla Foster for comments. This study was supported by NIH grants P50 CA097257 (DRR), R01 CA262311 (DRR), F32 CA213944 (STM), F30 CA246808 and T32 GM007618 (AC), U54 CA209891 (NJK), the Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Cancer Center (STM), the UCSF Wolfe Meningioma Program Project (STM, DRR), and the Trenchard Family Charitable Fund (DRR). Sequencing reactions were performed at the UCSF Center for Advanced Technology with support from the UCSF PBBR, RRP IMIA, and NIH grant S10 OD028511.

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41467-024-52284-8

Cite this

Eaton, C. D., Avalos, L., Liu, S. J., Chen, Z., Zakimi, N., Casey-Clyde, T., Bisignano, P., Lucas, C. H. G., Stevenson, E., Choudhury, A., Vasudevan, H. N., Magill, S. T., Young, J. S., Krogan, N. J., Villanueva-Meyer, J. E., Swaney, D. L., & Raleigh, D. R. (2024). Merlin^S13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features. Nature communications, 15(1), Article 7873. https://doi.org/10.1038/s41467-024-52284-8

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author = "Eaton, {Charlotte D.} and Lauro Avalos and Liu, {S. John} and Zhenhong Chen and Naomi Zakimi and Tim Casey-Clyde and Paola Bisignano and Lucas, {Calixto Hope G.} and Erica Stevenson and Abrar Choudhury and Vasudevan, {Harish N.} and Magill, {Stephen T.} and Young, {Jacob S.} and Krogan, {Nevan J.} and Villanueva-Meyer, {Javier E.} and Swaney, {Danielle L.} and Raleigh, {David R.}",

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Eaton, CD, Avalos, L, Liu, SJ, Chen, Z, Zakimi, N, Casey-Clyde, T, Bisignano, P, Lucas, CHG, Stevenson, E, Choudhury, A, Vasudevan, HN, Magill, ST, Young, JS, Krogan, NJ, Villanueva-Meyer, JE, Swaney, DL & Raleigh, DR 2024, 'Merlin^S13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features', Nature communications, vol. 15, no. 1, 7873. https://doi.org/10.1038/s41467-024-52284-8

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