Mesencephalic clefts with associated eye movement disorders

Wolf Dietrich A. Lagrèze*, Judith E.A. Warner, Amir A. Zamani, Gunnar K. Gouras, Igor J. Koralnik, Don C. Bienfang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: To describe two patients with mesencephalic midline clefts and associated eye movement disorders. Design: Case reports. Results: The first patient developed bilateral internuclear ophthalmoplegia with exotropia, reduced convergence, right ptosis, right fourth-nerve palsy, and right elevator palsy several years after meningitis with hydrocephalus. The second patient had bilateral internuclear ophthalmoplegia with exotropia, reduced convergence, bilateral ptosis, limited upward gaze, and right hypertropia since childhood. In both patients, magnetic resonance imaging showed a midline cleft extending from the cerebral aqueduct into the midbrain. Conclusion: It is likely that the clefts affected the oculomotor nuclei and medial longitudinal fasciculi, accounting for the eye movement disorders.

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalArchives of ophthalmology
Volume114
Issue number4
DOIs
StatePublished - Apr 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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