Mesoderm induction by activin requires FGF-mediated intracellular signals

Carole LaBonne, Malcolm Whitman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

209 Scopus citations


We have examined the role of FGF signaling during activin-mediated mesoderm induction in Xenopus. Using dominant inhibitory mutants of FGF signal transducers to disrupt the FGF-signaling pathway at the plasma membrane or in the cytosol prevents animal cap blastomeres from expressing several mesodermal markers in response to exogenous activin. Dominant inhibitory mutants of the FGF receptor, c-ras or c-raf inhibit the ability of activin to induce molecular markers of both dorsal and ventral mesoderm including Xbra, Mix1 and Xnot. Some transcriptional responses to activin such as goosecoid and Xwnt8 are inhibited less effectively than others, however, suggesting that there may differing requirements for an FGF signal in the responses of mesoderm-specific genes to activin induction. Despite the requirement for this signaling pathway during activin induction, downstream components of this pathway are not activated in response to activin, suggesting that activin does not signal directly through this pathway.

Original languageEnglish (US)
Pages (from-to)463-472
Number of pages10
Issue number2
StatePublished - Feb 1994


  • Activin
  • FGF
  • Mesoderm induction
  • Signal transduction
  • Xenopus

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


Dive into the research topics of 'Mesoderm induction by activin requires FGF-mediated intracellular signals'. Together they form a unique fingerprint.

Cite this