Mesolimbic dopamine receptor increases two weeks following hippocampal kindling

John G. Csernansky*, Steven Kerr, Raj Pruthi, Elisabeth S. Prosser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Kindled seizures developed in rats following repeated electrical stimulation of the left CA1 region of the hippocampus. Two weeks after the final kindled seizure, the densities of dopamine (DA) D2 receptors were assayed in the left and right amygdaloid area, nucleus accumbens, and nucleus caudatus. A significant increase (107%) in the density of DA D2-receptors in the ipsilateral nucleus accumbens occurred. This finding may help to define the long-term neurochemical consequences of kindling.

Original languageEnglish (US)
Pages (from-to)357-360
Number of pages4
JournalBrain research
Volume449
Issue number1-2
DOIs
StatePublished - May 24 1988

Keywords

  • -D
  • Dopamine receptor
  • Kindling
  • Nucleus accumbens
  • Receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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