Mesolimbic dopamine receptor increases two weeks following hippocampal kindling

John G. Csernansky; Steven Kerr; Raj Pruthi; Elisabeth S. Prosser

doi:10.1016/0006-8993(88)91053-0

Mesolimbic dopamine receptor increases two weeks following hippocampal kindling

John G. Csernansky^*, Steven Kerr, Raj Pruthi, Elisabeth S. Prosser

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Kindled seizures developed in rats following repeated electrical stimulation of the left CA1 region of the hippocampus. Two weeks after the final kindled seizure, the densities of dopamine (DA) D₂ receptors were assayed in the left and right amygdaloid area, nucleus accumbens, and nucleus caudatus. A significant increase (107%) in the density of DA D₂-receptors in the ipsilateral nucleus accumbens occurred. This finding may help to define the long-term neurochemical consequences of kindling.

Original language	English (US)
Pages (from-to)	357-360
Number of pages	4
Journal	Brain research
Volume	449
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(88)91053-0
State	Published - May 24 1988

Funding

This work was supportedb y a grant from the National Instituteo f Mental Health, MH-30854,t o the Men'al Health Clinical ResearchC enterat Stanford I_J..~versity( MHCRC), a grant from the Research Service of the Veterans Administrationt o the SchizophreniBai ologicR esearchC enter(SBRC) at the Palo Alto VeteransA dmimstratioMne dtcalC enter, and a grant from the John D. and CatherineT . MacArthur Foundationto the StanfordN ode of the MacArthur Network on the Psychobiologoyf Depression.T he authors thank Pamela J. Elliott for manuscripptr eparatioann de ditoriaal dvice.

Keywords

-D
Dopamine receptor
Kindling
Nucleus accumbens
Receptor

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/0006-8993(88)91053-0

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title = "Mesolimbic dopamine receptor increases two weeks following hippocampal kindling",

abstract = "Kindled seizures developed in rats following repeated electrical stimulation of the left CA1 region of the hippocampus. Two weeks after the final kindled seizure, the densities of dopamine (DA) D2 receptors were assayed in the left and right amygdaloid area, nucleus accumbens, and nucleus caudatus. A significant increase (107%) in the density of DA D2-receptors in the ipsilateral nucleus accumbens occurred. This finding may help to define the long-term neurochemical consequences of kindling.",

keywords = "-D, Dopamine receptor, Kindling, Nucleus accumbens, Receptor",

author = "Csernansky, {John G.} and Steven Kerr and Raj Pruthi and Prosser, {Elisabeth S.}",

note = "Funding Information: This work was supportedb y a grant from the National Instituteo f Mental Health, MH-30854,t o the Men'al Health Clinical ResearchC enterat Stanford I_J..~versity( MHCRC), a grant from the Research Service of the Veterans Administrationt o the SchizophreniBai ologicR esearchC enter(SBRC) at the Palo Alto VeteransA dmimstratioMne dtcalC enter, and a grant from the John D. and CatherineT . MacArthur Foundationto the StanfordN ode of the MacArthur Network on the Psychobiologoyf Depression.T he authors thank Pamela J. Elliott for manuscripptr eparatioann de ditoriaal dvice.",

year = "1988",

month = may,

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doi = "10.1016/0006-8993(88)91053-0",

language = "English (US)",

volume = "449",

pages = "357--360",

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TY - JOUR

T1 - Mesolimbic dopamine receptor increases two weeks following hippocampal kindling

AU - Csernansky, John G.

AU - Kerr, Steven

AU - Pruthi, Raj

AU - Prosser, Elisabeth S.

N1 - Funding Information: This work was supportedb y a grant from the National Instituteo f Mental Health, MH-30854,t o the Men'al Health Clinical ResearchC enterat Stanford I_J..~versity( MHCRC), a grant from the Research Service of the Veterans Administrationt o the SchizophreniBai ologicR esearchC enter(SBRC) at the Palo Alto VeteransA dmimstratioMne dtcalC enter, and a grant from the John D. and CatherineT . MacArthur Foundationto the StanfordN ode of the MacArthur Network on the Psychobiologoyf Depression.T he authors thank Pamela J. Elliott for manuscripptr eparatioann de ditoriaal dvice.

PY - 1988/5/24

Y1 - 1988/5/24

N2 - Kindled seizures developed in rats following repeated electrical stimulation of the left CA1 region of the hippocampus. Two weeks after the final kindled seizure, the densities of dopamine (DA) D2 receptors were assayed in the left and right amygdaloid area, nucleus accumbens, and nucleus caudatus. A significant increase (107%) in the density of DA D2-receptors in the ipsilateral nucleus accumbens occurred. This finding may help to define the long-term neurochemical consequences of kindling.

AB - Kindled seizures developed in rats following repeated electrical stimulation of the left CA1 region of the hippocampus. Two weeks after the final kindled seizure, the densities of dopamine (DA) D2 receptors were assayed in the left and right amygdaloid area, nucleus accumbens, and nucleus caudatus. A significant increase (107%) in the density of DA D2-receptors in the ipsilateral nucleus accumbens occurred. This finding may help to define the long-term neurochemical consequences of kindling.

KW - -D

KW - Dopamine receptor

KW - Kindling

KW - Nucleus accumbens

KW - Receptor

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EP - 360

JO - Brain research

JF - Brain research

IS - 1-2

ER -

Mesolimbic dopamine receptor increases two weeks following hippocampal kindling

Abstract

Funding

Keywords

ASJC Scopus subject areas

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