Mesostructured silica for optical functionality, nanomachines, and drug delivery

Yaroslav Klichko, Monty Liong, Eunshil Choi, Sarah Angelos, Andre E. Nel, J. Fraser Stoddart, Fuyuhiko Tamanoi, Jeffrey I. Zink

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Silica thin films and nanoparticles prepared using sol-gel chemistry are derivatized with active molecules to generate new functional materials. The mild conditions associated with sol-gel processing allow for the incorporation of a range of dopants including organic or inorganic dyes, biomolecules, surfactants, and molecular machines. Silica nanoparticles embedded with inorganic nanocrystals, and films containing living cells have also been synthesized. Silica templated with surfactants to create mesostructure contains physically and chemically different regions that can be selectively derivatized using defined techniques to create dynamic materials. Using two different techniques, donor-acceptor pairs can be doped into separated regions simultaneously and photo-induced electron transfer between the molecules can be measured. Mesoporous silica materials are also useful supports for molecular machines. Machines including snap-tops and nanoimpellers that are designed to control the release of guest molecules trapped within the pores are described. Mesoporous silica nanoparticles are promising materials for drug delivery and other biomedical applications because they are nontoxic and can be taken up by living cells. Through appropriate design and synthesis, multifunctional mesoporous silica nanoparticles for sophisticated bio-applications are created.

Original languageEnglish (US)
Pages (from-to)S2-S10
JournalJournal of the American Ceramic Society
Volume92
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 2009

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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