Meta-analysis of selected toxicity endpoints of CDK4/6 inhibitors: Palbociclib and ribociclib

R. Costa*, R. B. Costa, Sarah M. Talamantes, Irene Helenowski, Jonna Peterson, Jason Kaplan, B. A. Carneiro, Francis J. Giles, W. J. Gradishar

*Corresponding author for this work

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Purpose Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors such as palbociclib and ribociclib are associated with distinct adverse effects (AEs) compared to other targeted therapies. This meta-analysis of clinical trials summarizes these agents’ toxicity profile. Methods A librarian-guided literature search was conducted in March of 2017. The trials needed to have at least one of the study arms consisting of palbociclib or ribociclib monotherapy at currently FDA approved dose regimens. Heterogeneity across studies was analyzed using I2 statistics. Data were analyzed using random effects meta-analysis for absolute risks. Results Seven randomized trials and 1,332 patients were included in our meta-analysis. There was evidence of significant heterogeneity between studies for serious AEs but not for death. The pooled absolute risk (AR) for all-causality serious AEs and treatment-related death were 16% and 0%, respectively. Patients treated with CDK 4/6 inhibitors had an AR of grade 3/4 neutropenia of 61%; neutropenic fever and infections were rare (1% and 3%, respectively). Grade 3/4 nausea, vomiting, and rash were rare. There was no significant correlation between age of patients at study entry and the risk of grade 3/4 neutropenia. Conclusion Treatment with CDK 4/6 inhibitors is well tolerated and associated with a low risk of treatment-related deaths. There is an increased AR of grade 3/4 neutropenia but a low AR of associated infections.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBreast
Volume35
DOIs
StatePublished - Oct 2017

Keywords

  • Infection
  • Neutropenia
  • Palbociclib
  • Ribociclib

ASJC Scopus subject areas

  • Surgery

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    Costa, R., Costa, R. B., Talamantes, S. M., Helenowski, I., Peterson, J., Kaplan, J., Carneiro, B. A., Giles, F. J., & Gradishar, W. J. (2017). Meta-analysis of selected toxicity endpoints of CDK4/6 inhibitors: Palbociclib and ribociclib. Breast, 35, 1-7. https://doi.org/10.1016/j.breast.2017.05.016