Metabolic and inflammatory genes in schizophrenia

Kayla A. Chase, Cherise Rosen, Hannah Gin, Olivia Bjorkquist, Benjamin Feiner, Robert Marvin, Sean Conrin, Rajiv P. Sharma*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.

Original languageEnglish (US)
Pages (from-to)208-211
Number of pages4
JournalPsychiatry Research
Volume225
Issue number1-2
DOIs
StatePublished - Jan 30 2015

Keywords

  • Inflammation
  • Obesity
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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