Metabolic and inflammatory genes in schizophrenia

Kayla A. Chase; Cherise Rosen; Hannah Gin; Olivia Bjorkquist; Benjamin Feiner; Robert Marvin; Sean Conrin; Rajiv P. Sharma

doi:10.1016/j.psychres.2014.11.007

Metabolic and inflammatory genes in schizophrenia

Kayla A. Chase, Cherise Rosen, Hannah Gin, Olivia Bjorkquist, Benjamin Feiner, Robert Marvin, Sean Conrin, Rajiv P. Sharma^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.

Original language	English (US)
Pages (from-to)	208-211
Number of pages	4
Journal	Psychiatry Research
Volume	225
Issue number	1-2
DOIs	https://doi.org/10.1016/j.psychres.2014.11.007
State	Published - Jan 30 2015

Keywords

Inflammation
Obesity
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2014.11.007

Cite this

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title = "Metabolic and inflammatory genes in schizophrenia",

abstract = "Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.",

keywords = "Inflammation, Obesity, Schizophrenia",

author = "Chase, {Kayla A.} and Cherise Rosen and Hannah Gin and Olivia Bjorkquist and Benjamin Feiner and Robert Marvin and Sean Conrin and Sharma, {Rajiv P.}",

note = "Funding Information: This work was supported in part by PHS grant (NIH) R01MH094358 (RPS). Publisher Copyright: {\textcopyright} 2014.",

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T1 - Metabolic and inflammatory genes in schizophrenia

AU - Chase, Kayla A.

AU - Rosen, Cherise

AU - Gin, Hannah

AU - Bjorkquist, Olivia

AU - Feiner, Benjamin

AU - Marvin, Robert

AU - Conrin, Sean

AU - Sharma, Rajiv P.

PY - 2015/1/30

Y1 - 2015/1/30

N2 - Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.

AB - Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.

KW - Inflammation

KW - Obesity

KW - Schizophrenia

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Metabolic and inflammatory genes in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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