Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

Richard C. Scarpulla*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

656 Scopus citations

Abstract

The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network governing the transcriptional control of mitochondrial biogenesis and respiratory function. These coactivators target multiple transcription factors including NRF-1, NRF-2 and the orphan nuclear hormone receptor, ERRα, among others. In addition, they themselves are the targets of coactivator and co-repressor complexes that regulate gene expression through chromatin remodeling. The expression of PGC-1 family members is modulated by extracellular signals controlling metabolism, differentiation or cell growth and in some cases their activities are known to be regulated by post-translational modification by the energy sensors, AMPK and SIRT1. Recent gene knockout and silencing studies of many members of the PGC-1 network have revealed phenotypes of wide ranging severity suggestive of complex compensatory interactions or broadly integrative functions that are not exclusive to mitochondrial biogenesis. The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.

Original languageEnglish (US)
Pages (from-to)1269-1278
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1813
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Coactivator
  • Gene expression
  • Mitochondria
  • Regulation
  • Respiration
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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