Metabolic Implications of Circadian–HIF Crosstalk

Clara B. Peek*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Research over the past few decades has shed light on the mechanisms underlying the link between circadian disruption and the development of metabolic diseases such as obesity, type 2 diabetes, and cancer. However, how the clock network interacts with tissue-specific nutrient-sensing pathways during conditions of nutrient stress or pathological states remains incompletely understood. Recent work has demonstrated that the circadian clock can ‘reprogram’ the transcriptome to control distinct sets of genes during altered nutrient conditions, such as high fat diet, aging, and exercise. In this review, I discuss connections between circadian clock transcription factors and the oxygen- and nutrient-responsive hypoxia-inducible factor (HIF) pathway. I highlight recently uncovered mechanistic insights underlying these pathway interactions and address potential implications for the role of circadian disruption in metabolic diseases.

Original languageEnglish (US)
Pages (from-to)459-468
Number of pages10
JournalTrends in Endocrinology and Metabolism
Issue number6
StatePublished - Jun 2020

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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