Metabolic polymoryphisms, smoking, and oral cancer in Puerto Rico

Heng Xie, Lifang Hou, Peter G. Shields, Deborah M. Winn, Gloria Gridley, Eleuterio Bravo-Otero, Scott R. Diehl, Elise D. Bowman, Linda M. Brown, Richard B. Hayes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Genetic polymorphisms resulting in variation in metabolism of tobacco carcinogens may influence oral cancer risk. In a population-based case-control study in Puerto Rico, genotypes of CYP1A1, GSTM1, and GSTT1 were determined by a PCR-based method for 132 oral cancer patients and 143 control subjects. Genotype-associated risks were estimated by logistic regression. The null variant of GSTM1 was associated with a marginally significant decrease in oral cancer risk [odds ratio (OR) = 0.6, 95% confidence interval (CI) = 0.3-1.0, and P for trend = 0.09]. Risks increased with increasing cigarette use among subjects with the GSTM1-present genotype (P for trend <0.0001), rising to OR = 9.5, 95% CI = 3.0-30, among the heaviest cigarette users. In contrast, among subjects with the GSTM1-null genotype, risks did not clearly increase with increasing cigarette use (P for trend <0.61; OR= 1.8, 95% CI = 0.6-5.2 among the heaviest tobacco users). The GSTT1-null variant (OR = 1.0, 95% CI = 0.5-1.9) and CYP1A1462Val variant (OR= 0.9, 95% CI = 0.5-1.7) were not associated with the risk. Risks rose with increasing cigarette use in a similar manner for subjects with or without the CYP1A1462Val variant (P for interaction = 0.3) and for subjects with or without the GSTT1-null genotype (P for interaction = 0.4). In conclusion, cigarette use significantly increased the risk of oral cancer in this population. The GSTM1-present genotype was associated with higher tobacco-associated risk for oral cancer among heavy smokers than the null genotype.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalOncology Research
Volume14
Issue number6
DOIs
StatePublished - Jan 1 2003

Keywords

  • Carcinoma
  • Enzymes
  • Polymorphism
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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