Metabolic regulation and energy homeostasis through the primary cilium

Edwin C. Oh*, Shivakumar Vasanth, Elias Nicholas Katsanis

*Corresponding author for this work

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Obesity and diabetes represent a significant healthcare concern. In contrast to genome-wide association studies that, some exceptions notwithstanding, have offered modest clues about pathomechanism, the dissection of rare disorders in which obesity represents a core feature have highlighted key molecules and structures critical to energy regulation. Here we focus on the primary cilium, an organelle whose roles in energy homeostasis have been underscored by the high incidence of obesity and type II diabetes in patients and mouse mutants with compromised ciliary function. We discuss recent evidence linking ciliary dysfunction to metabolic defects and we explore the contribution of neuronal and nonneuronal cilia to these phenotypes.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
JournalCell Metabolism
Volume21
Issue number1
DOIs
StatePublished - Jan 6 2015

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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