Metabolic syndrome and infertility in men

Christopher D. Morrison*, Robert E. Brannigan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Metabolic syndrome is a compilation of symptoms including central obesity, insulin resistance, dyslipidemia, and hypertension. Initially used to predict cardiovascular disease, it is now clear that the molecular and physiologic abnormalities seen in metabolic syndrome extend well beyond the cardiovascular system. Growing evidence has linked metabolic syndrome and its individual symptoms to the increasing prevalence of male infertility. This manuscript reviews the recent evidence connecting metabolic syndrome to male infertility as well as the underlying pathophysiology. Currently, there are limited prospective studies examining the effects of treating metabolic syndrome on male reproduction and these relationships will need to be a focus of further investigation.

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
Volume29
Issue number4
DOIs
StatePublished - May 1 2015

Keywords

  • dyslipidemia
  • hypogonadism
  • inflammation
  • insulin resistance
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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