Metabolic syndrome management

Neil J. Stone*, Lowell R. Schmeltz

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Overweight, obesity and the metabolic syndrome occur in genetically susceptible individuals with environmental influences, and may be further compounded by other disorders of metabolism or pharmacological therapy that increase insulin resistance or promotes weight gain. Treatment of the metabolic syndrome should focus on treatment of each individual component first. Lifestyle modification, including diet and exercise with a goal of weight reduction, is the foundation of any successful treatment regimen for the metabolic syndrome. Pharmacological therapy should be individualized and targeted to normalize blood pressure, HDL cholesterol, triglycerides and glucose values. If successful, comprehensive management of the metabolic syndrome promises to delay or prevent the development of coronary heart disease and Type 2 diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)2059-2075
Number of pages17
JournalExpert Opinion on Pharmacotherapy
Issue number13
StatePublished - Sep 2007


  • Coronary artery disease
  • Coronary prevention
  • Coronary risk
  • Dyslipidemia
  • Glucose intolerance
  • Hypertension
  • Insulin resistance
  • Metabolic syndrome
  • Obesity
  • T2DM

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology


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