Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome

Lauren M. Petrick*, Karan Uppal, William E. Funk

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Purpose of reviewExposomics studies can measure health-relevant chemical exposures during a lifetime and estimate the 'internal' environment. However, sampling limitations make these features difficult to capture directly during the critical neonatal time period.Recent findingsWe review the use of newborn dried bloodspots (DBS) archived from newborn screening programs for exposomic analysis in epidemiological children's health studies. Emerging 'omics technologies such as adductomics and metabolomics have been adapted for DBS analysis, and these technologies can now provide valuable etiological information on the complex interplay between exposures, biological response, and population phenotypes.SummaryAdductomics and metabolomics of DBS can provide robust measurements for retrospective epidemiological investigations. With extensive bioarchiving programs in the United States and other countries, DBS are poised to substantially aid epidemiological studies, particularly for rare and low-frequency childhood diseases and disorders.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalCurrent opinion in pediatrics
Volume32
Issue number2
DOIs
StatePublished - Apr 1 2020

Keywords

  • adductomics
  • archived dried bloodspot
  • biomarker
  • exposome
  • exposure
  • metabolomics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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