Abstract
Purpose of reviewExposomics studies can measure health-relevant chemical exposures during a lifetime and estimate the 'internal' environment. However, sampling limitations make these features difficult to capture directly during the critical neonatal time period.Recent findingsWe review the use of newborn dried bloodspots (DBS) archived from newborn screening programs for exposomic analysis in epidemiological children's health studies. Emerging 'omics technologies such as adductomics and metabolomics have been adapted for DBS analysis, and these technologies can now provide valuable etiological information on the complex interplay between exposures, biological response, and population phenotypes.SummaryAdductomics and metabolomics of DBS can provide robust measurements for retrospective epidemiological investigations. With extensive bioarchiving programs in the United States and other countries, DBS are poised to substantially aid epidemiological studies, particularly for rare and low-frequency childhood diseases and disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 300-307 |
| Number of pages | 8 |
| Journal | Current opinion in pediatrics |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2020 |
Funding
The authors are supported by the National Institute of Environmental Health Sciences grants 2U2CES026561-02 (L.P.), 1U2CES030859-01 (L.P.), P30ES23515 (L.P.), R21ES030882-01 (L.P.), R21ES026776-01 (W.F.), and U24OD023319-01 (W.F.); National Institute on Alcohol Abuse and Alcoholism grant R21AA026928-02 (K.U.); National Institute of Diabetes and Digestive and Kidney Diseases grant U24DK112341 (K.U.); and National Institute on Aging grant RF1AG057470 (K.U.).
Keywords
- adductomics
- archived dried bloodspot
- biomarker
- exposome
- exposure
- metabolomics
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health