Metal complexes as enzyme inhibitors

Angelique Y. Louie; Thomas J. Meade; S. J. Lippard

doi:10.1021/cr9804285

Metal complexes as enzyme inhibitors

Angelique Y. Louie, Thomas J. Meade, S. J. Lippard

Chemistry

Research output: Contribution to journal › Article › peer-review

290 Scopus citations

Abstract

Metal complexes are gaining wider applications as enzyme inhibitors for disease treatments. Factors such as specificity, bioavailability, compensatory effects and complex stability are taken into account before such complexes function as therapeutic agents. The applications of metal complex enzyme inhibitors to normal and abnormal physiology, infections and toxicity are discussed.

Original language	English (US)
Pages (from-to)	2711-2734
Number of pages	24
Journal	Chemical Reviews
Volume	99
Issue number	9
DOIs	https://doi.org/10.1021/cr9804285
State	Published - Sep 1 1999

ASJC Scopus subject areas

Chemistry(all)

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10.1021/cr9804285

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title = "Metal complexes as enzyme inhibitors",

abstract = "Metal complexes are gaining wider applications as enzyme inhibitors for disease treatments. Factors such as specificity, bioavailability, compensatory effects and complex stability are taken into account before such complexes function as therapeutic agents. The applications of metal complex enzyme inhibitors to normal and abnormal physiology, infections and toxicity are discussed.",

author = "Louie, {Angelique Y.} and Meade, {Thomas J.} and Lippard, {S. J.}",

year = "1999",

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AU - Louie, Angelique Y.

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N2 - Metal complexes are gaining wider applications as enzyme inhibitors for disease treatments. Factors such as specificity, bioavailability, compensatory effects and complex stability are taken into account before such complexes function as therapeutic agents. The applications of metal complex enzyme inhibitors to normal and abnormal physiology, infections and toxicity are discussed.

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Metal complexes as enzyme inhibitors

Abstract

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