Abstract
The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.
| Original language | English (US) |
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| Patent number | 7033760 |
| Filing date | 8/3/01 |
| State | Published - Apr 25 2006 |